There quercetin it's a flavonoid which we cannot find in isolated form, in nature, but as a non-sugary part of some glycosides including rutin and quercitrin. For this reason it can be called aglycone. Thus, we can find it in many extracts, for example in those of horse chestnut, gingko biloba, calendula, hawthorn, chamomile, lovage and hypericum.
We can also hear about quercetin, a vowel changes but it always remains the same substance, the one we find not only in the extracts of many plants and trees but also in fruits and vegetables. Among the vegetables with a greater quantity of this flavonoid, we find tomatoes, onions, broccoli and capers, among the fruits instead apples, grapes, olives, citrus fruits, berries. Let's not forget the contribution of quercetin which is also present in beverages such as tea and red wine.
Very often we may find this as an ingredient flavonoid in anti-aging products or products with an antioxidant effect, this is due to its antioxidant and anti-inflammatory properties. We can also meet it in the treatment and prevention of some diseases, there are in fact numerous studies underway that would demonstrate its potential usefulness in this field too.
When treating problems such as hemorrhoids, venous insufficiency and capillary fragility we find some glycosides applied such as rutin which contains our quercetin and which can act as an anti-haemorrhagic and anti-edema. It would therefore be an excellent remedy for night cramps, pains, heaviness and swelling in the legs.
Thanks to his antiplatelet and antithrombotic activity, it can also help reduce cardiovascular risk but more often we find this flavonoid used to combat premature skin aging. Whether taken orally or topically, quercetin is able to counteract the negative activity of solar radiation which favors the synthesis of free radicals, which in turn are responsible for structural alterations in the synthesis of collagen and elastin by dermal fibroblasts.
Another type of disease that the quercetin it can counteract that of diseases related to oxidative stress and chronic inflammation. Allergies and insulin resistance, for example, but also atherosclerosis, arthritis and Alzheimer's disease, psoriasis, lupus and many others related toaging. In this context, the flavonoid is able to block the release of histamine and the production of prostaglandins and leukotrienes with pro-inflammatory action, as well as the 5-lipoxygenase and phospholipase A2 enzymes.
At the same time it also has a powerful antioxidant effect, both direct and indirect, protecting the activity of enzymatic systems endogenous antioxidants.
Studies have also been carried out on the action of this substance in cancer prevention for example, it could be used in these circumstances if combined with chemotherapeutic agents with the function of adjuvant. Obviously it must be up to the doctor to decide if this is the case. What has been noted so far is that both in vitro and in animal models, this substance appears to be able to stop the growth or even lead to cell death of colonies of tumor cells of different origins in different stages of replication.
There are numerous studies in progress but for now it would seem to confirm the valuable role of quercetin in fight the action of free radicals and inflammation. There are different opinions and certainties when it comes to the effectiveness of this flavonoid in the treatment of cancers of this type. A great deal of in vitro research or on animal models has been carried out and continued to be carried out, but for now there are no large-scale clinical studies that confirm the usefulness of quercetin in the treatment of this type of disease.
For adults with normal weight intake dose recommended is around 500 mg / day, we take into account that following a balanced and regular Western diet, we usually take about 30 mg daily.
In evaluating what we eat and what we actually absorb, it is important to know that we are better able to absorb glycosylated forms than isolated quercetin. This makes us understand how it is very important not only to identify the foods that contain it in general quercetin but also to distinguish those that may be more suitable for us to make it bioavailable.
There are no strong contraindications regarding the use of this flavonoid and the products that contain it, with the exception of those who are following pharmaceutical treatments with antiplatelet agents (eg. Aspirinetta, CardioAspirin) and oral anticoagulants (eg. Coumadin, Sintrom). In this case it is necessary to avoid quercetin due to its antiplatelet and antithrombotic activity.
There are studies that are also investigating the mutagenic activity of this substance but there are currently no
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